Calamine clear lotion is a medicated skin protectant and external analgesic that provides fast, non-greasy relief from itching and discomfort caused by insect bites, poison ivy/oak/sumac, and minor rashes by cooling the skin and drying oozing/weeping irritations. It often contains active ingredients like zinc oxide and pramoxine HCl, works by creating a barrier and providing a cooling sensation as it evaporates, and is used for various skin issues beyond plant reactions, including chickenpox and mild eczema.

